The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis
S Liu, R Yin, Z Yang, F Wei, J Hu - Frontiers in Immunology, 2022 - frontiersin.org
Background Rhubarb is an important traditional Chinese medicine, and rhein is one of its
most important active ingredients. Studies have found that rhein can improve ulcerative …
most important active ingredients. Studies have found that rhein can improve ulcerative …
Role of differentiated embryo-chondrocyte expressed gene 2 in immunity
Y Li, Y Ma, Y Liu, N Tang, W Zhang, J Huo… - Frontiers in …, 2024 - frontiersin.org
Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-
loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor …
loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor …
The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression
JS Park, M Kang, HB Kim, H Hong, J Lee… - Nature …, 2024 - nature.com
Follicular B (FOB) and marginal zone B (MZB) cells are pivotal in humoral immune
responses against pathogenic infections. MZB cells can exacerbate endotoxic shock via …
responses against pathogenic infections. MZB cells can exacerbate endotoxic shock via …
B Cells of Early-life Origin Defined by RAG2-based Lymphoid Cell Tracking under Native Hematopoietic Conditions
K Fujisaki, S Okazaki, S Ogawa, M Takeda… - The Journal of …, 2024 - journals.aai.org
During the perinatal period, the immune system sets the threshold to select either response
or tolerance to environmental Ags, which leads to the potential to provide a lifetime of …
or tolerance to environmental Ags, which leads to the potential to provide a lifetime of …
ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth
Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional
repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic …
repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic …
BHLHE41 inhibits bladder cancer progression via regulation of PYCR1 stability and thus inactivating PI3K/AKT signaling pathway
S Xiao, J Chen, Y Wei, W Song - European Journal of Medical Research, 2024 - Springer
Background The basic helix-loop-helix family member e41 (BHLHE41) is frequently
dysregulated in tumors and plays a crucial role in malignant progression of various cancers …
dysregulated in tumors and plays a crucial role in malignant progression of various cancers …
BHLHE41 Overexpression Alleviates the Malignant Behavior of Colon Cancer Cells Induced by Hypoxia via Modulating HIF‐1α/EMT Pathway
S Chen, QJ Dong, ZA Wan, S Gao… - Gastroenterology …, 2022 - Wiley Online Library
Objective. BHLHE41 has been shown to be a marker of tumorigenesis. Colon cancer (CC) is
a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of …
a common malignant tumor of colonic mucosa. This study mainly explored the mechanism of …
[HTML][HTML] Generation of hematopoietic lineage cell-specific chimeric mice using retrovirus-transduced fetal liver cells
H Hong, Y Lee - STAR protocols, 2022 - Elsevier
Hematopoietic lineage cell-specific transgenic or knockout mice provide a valuable platform
to identify the role of specific genes in hematopoiesis in vivo. Here, we describe protocols for …
to identify the role of specific genes in hematopoiesis in vivo. Here, we describe protocols for …