Melanocortins are a highly conserved family of peptides and receptors that includes multiple
proopiomelanocortin-derived peptides and five defined melanocortin receptors. The …

Background Chronic rhinosinusitis (CRS) is usually accompanied by mucin hypersecretion
that can lead to mucus accumulation and impair nasal mucociliary clearance, thus …

BACKGROUND: Little is known about the effect of neuropeptides on basophils, which are
important effector cells in immune and allergic responses. OBJECTIVE: This study aimed at …

Ocular allergic diseases are frequently seen in ophthalmological clinical practice.
Immunological damage is mediated by a local Th2 inflammatory microenvironment …

Alpha melanocyte stimulating hormone (αMSH) abates inflammation in multiple tissues,
while Forkhead box proteins O (FoxOs) stimulate inflammatory cascade. However, the …

Mucins are highly glycosylated secretary proteins produced by most epithelial cells.
Hypersecretion of mucins is one of the prominent symptoms of several airway diseases …

Alpha melanocyte stimulating hormone (αMSH) has been shown to have anti‐inflammatory
and anticachectic actions. We hypothesized that αMSH administration could attenuate the …

Introduction Mechanical injury can greatly influence articular cartilage, propagating
inflammation, cell injury and death–risk factors for the development of osteoarthritis …

Despite the high expectations associated with the recent introduction of CFTR modulators,
airway inflammation still remains a relevant clinical issue in cystic fibrosis (CF). The classical …

Methods TNFα and rhino syncitial virus (RSV)-evoked nuclear factor-κB (NFκB) signaling
was measured in immortalised human bronchial epithelial cells (16HBE14o-) in response to …