α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to
play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α …

Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …

With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved
over-lapping genes to maximise the usage of its genome. An example is the recently found …

The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for
Alzheimer's disease, although it only differs from its neutral counterpart ApoE3 by a single …

Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of
cargo within cilia, but how this cargo is selectively transported to cilia is unclear …

The influenza A M2 homotetrameric channel consists of four transmembrane (TM) and four
amphipathic helices (AHs). This viral proton channel is suggested to form clusters in the …

Ciliary extracellular vesicle (EV) shedding is evolutionarily conserved. In Chlamydomonas
and C. elegans, ciliary EVs act as signaling devices. 1–3 In cultured mammalian cells, ciliary …

The plant trans-Golgi network (TGN) is a central trafficking hub where secretory, vacuolar,
recycling, and endocytic pathways merge. Among currently known molecular players …

Vip3 proteins are produced by Bacillus thuringiensis and are toxic against lepidopterans,
reason why the vip3Aa gene has been introduced into cotton and corn to control agricultural …

Continuous reshaping of the plasma membrane into pleomorphic shapes is critical for a
plethora of cellular functions. How the cell carries out this enigmatic control of membrane …