Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput …

T Deschamps, H Waisner, C Dogrammatzis… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) has infected more than 80% of the population.
Reactivation of the virus causes diseases ranging in severity from benign cold sores to fatal …

Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses

VV Khrustalev, EV Barkovsky - International journal of …, 2011 - inderscienceonline.com
The usage of cytosine in third codon positions of 22 complete Rubella virus genomes
(52.4%) is significantly higher than the usage of guanine (28.9%), adenine (6.9%) and uracil …

Mutational pressure is a cause of inter-and intragenomic differences in GC-content of simplex and varicello viruses

VV Khrustalev, EV Barkovsky - Computational Biology and Chemistry, 2009 - Elsevier
Total GC-content (G+ C), GC-content in codon positions and 0-fold, 2-fold and 4-fold
degenerated sites in all coding districts from 10 completely sequenced genomes of simplex …

Study of completed archaeal genomes and proteomes: hypothesis of strong mutational AT pressure existed in their common predecessor

VV Khrustalev, EV Barkovsky - Genomics, Proteomics and …, 2010 - academic.oup.com
The number of completely sequenced archaeal genomes has been sufficient for a large-
scale bioinformatic study. We have conducted analyses for each coding region from 36 …

Low rates of synonymous mutations in sequences of Mycobacterium tuberculosis GyrA and KatG genes

VV Khrustalev, M Arjomandzadegan, EV Barkovsky… - Tuberculosis, 2012 - Elsevier
Partial sequences of KatG and GyrA genes have been obtained from multi and extensively
drug-resistant (MDR and XDR) clinical isolates of Mycobacterium tuberculosis …

HIV1 V3 loop hypermutability is enhanced by the guanine usage bias in the part of env gene coding for it

VV Khrustalev - In silico biology, 2009 - content.iospress.com
Guanine is the most mutable nucleotide in HIV genes because of frequently occurring G to A
transitions, which are caused by cytosine deamination in viral DNA minus strands catalyzed …

Levels of HIV1 gp120 3D B-cell epitopes mutability and variability: Searching for possible vaccine epitopes

VV Khrustalev - Immunological Investigations, 2010 - Taylor & Francis
We used a DiscoTope 1.2 (http://www. cbs. dtu. dk/services/DiscoTope/), Epitopia
(http://epitopia. tau. ac. il/) and EPCES (http://www. t38. physik. tu-muenchen. de/programs …

Can mutational GC-pressure create new linear B-cell epitopes in herpes simplex virus type 1 glycoprotein B?

VV Khrustalev - Immunological Investigations, 2009 - Taylor & Francis
We showed that GC-content of nucleotide sequences coding for linear B-cell epitopes of
herpes simplex virus type 1 (HSV1) glycoprotein B (gB) is higher than GC-content of …

[PDF][PDF] Main pathways of proteome simplification in alphaherpesviruses under the influence of the strong mutational GC-pressure

VV Khrustalev, EV Barkovsky - J. Proteomics Bioinform, 2009 - Citeseer
The simplification of amino acid content distribution under the influence of the strong
mutational pressure takes place in simplex and varicello viruses proteins coded by genes …

Zebra Finch Glucokinase Containing Two Homologous Halves Is an In Silico Chimera

KV Victorovich, LS Vladimirovich… - International Scholarly …, 2013 - Wiley Online Library
Chimerical nature of the gene annotated as Zebra finch (Taeniopygia guttata) glucokinase
(hexokinase IV) has been proved in this study. N‐half of the protein encoded by that gene …