Molecular approaches to determine the multiplicity of Plasmodium infections

D Zhong, C Koepfli, L Cui, G Yan - Malaria journal, 2018 - Springer
Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …

Transmission-blocking vaccines: old friends and new prospects

FK Acquah, J Adjah, KC Williamson… - Infection and …, 2019 - Am Soc Microbiol
In the progression of the life cycle of Plasmodium falciparum, a small proportion of asexual
parasites differentiate into male or female sexual forms called gametocytes. Just like their …

A human antibody epitope map of the malaria vaccine antigen Pfs25

N Shukla, WK Tang, CH Coelho, CA Long, SA Healy… - npj Vaccines, 2023 - nature.com
Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate
transmission-blocking activity and induction of rapidly decreasing antibody titers in clinical …

Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon

TN Metoh, JH Chen, P Fon-Gah, X Zhou… - Malaria Journal, 2020 - Springer
Background Malaria is a major public health problem in Cameroon. The study of the genetic
diversity within parasite population is essential for understanding the mechanism underlying …

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium …

M Pritam, G Singh, S Swaroop, AK Singh, SP Singh - BMC bioinformatics, 2019 - Springer
Background In the current scenario, designing of world-wide effective malaria vaccine
against Plasmodium falciparum remain challenging despite the significant progress has …

Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India

SJ Patgiri, K Sarma, N Sarmah, N Bhattacharyya… - Scientific Reports, 2019 - nature.com
Monitoring of anti-malarial drug resistance is vital in Northeast India as this region shares its
international border with Southeast Asia. Genetic diversity of Plasmodium parasites …

Genetic polymorphism of Plasmodium falciparum msp-1, msp-2 and glurp vaccine candidate genes in pre-artemisinin era clinical isolates from Lakhimpur district in …

V Sathishkumar, T Nirmolia… - Access …, 2022 - microbiologyresearch.org
Background. Northeast India shares its international border with Southeast Asia and has a
number of malaria endemic zones. Monitoring genetic diversity of malaria parasites is …

Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, North East Ethiopia based on the merozoite surface protein-2 (msp-2) gene as a …

H Mohammed, A Assefa, M Chernet, Y Wuletaw… - Malaria Journal, 2021 - Springer
Background The characterization of parasite populations circulating in malaria endemic
areas is necessary to evaluate the success of ongoing interventions and malaria control …

Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya

KO Ochwedo, SA Onyango, CJ Omondi, PW Orondo… - Plos one, 2022 - journals.plos.org
Background Leading transmission-blocking vaccine candidates such as Plasmodium
falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may …

Plasmodium vivax AMA1: Implications of distinct haplotypes for immune response

NC Bittencourt, ABIE Silva, NS Virgili… - PLoS Neglected …, 2020 - journals.plos.org
In Brazil, Plasmodium vivax infection accounts for around 80% of malaria cases. This
infection has a substantial impact on the productivity of the local population as the course of …