[HTML][HTML] Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy

C Chen, G Wang - World journal of hepatology, 2015 - ncbi.nlm.nih.gov
The incidence and mortality of hepatocellular carcinoma (HCC) have fallen dramatically in
China and elsewhere over the past several decades. Nonetheless, HCC remains a major …

[HTML][HTML] The role of branched-chain amino acid supplementation in combination with locoregional treatments for hepatocellular carcinoma: systematic review and …

GA Sideris, S Tsaramanidis, AT Vyllioti, N Njuguna - Cancers, 2023 - mdpi.com
Simple Summary The use of branched-chain amino acid (BCAA) supplements in patients
with cirrhosis and liver cancer has been investigated by numerous studies, with multiple …

Muscle volume loss as a prognostic marker in hepatocellular carcinoma patients treated with sorafenib

A Hiraoka, M Hirooka, Y Koizumi… - Hepatology …, 2017 - Wiley Online Library
Aim To elucidate the clinical significance of muscle wasting in regard to survival of
hepatocellular carcinoma (HCC) patients undergoing sorafenib treatment, we evaluated …

Sarcopenia is a risk factor for the recurrence of hepatocellular carcinoma after curative treatment

S Kamachi, T Mizuta, T Otsuka, S Nakashita… - Hepatology …, 2016 - Wiley Online Library
Background and Aim Sarcopenia, initially proposed as decreased of muscle mass and
strength, is associated with aging and malignant diseases. The aim of the present study was …

[HTML][HTML] Prognostic significance of sarcopenia in patients with hepatocellular carcinoma treated with lenvatinib: A retrospective analysis

D Dong, JY Shi, X Shang, B Liu, WL Xu, GZ Cui… - Medicine, 2022 - journals.lww.com
Our study investigated the correlation between sarcopenia and clinical outcomes in patients
with hepatocellular carcinoma (HCC) treated with lenvatinib. We retrospectively evaluated …

[HTML][HTML] Influence of skeletal muscle volume loss during lenvatinib treatment on prognosis in unresectable hepatocellular carcinoma: a multicenter study in Tohoku …

M Fujita, K Abe, H Kuroda, T Oikawa, M Ninomiya… - Scientific Reports, 2022 - nature.com
Sarcopenia is associated with poor prognosis of patients with hepatocellular carcinoma
(HCC). We investigated the association of skeletal muscle volume (SMV) and its change in …

Systematic review with meta‐analysis: Branched‐chain amino acid supplementation in liver disease

AM van Dijk, AS Bruins Slot… - European journal of …, 2023 - Wiley Online Library
Background Dietary supplementation with branched‐chain amino acids (BCAA) is often
used in cirrhotic patients to improve nutritional status. We wanted to explore the evidence for …

Clinical outcomes of sorafenib treatment failure for advanced hepatocellular carcinoma and candidates for regorafenib treatment in real‐world practice

S Uchikawa, T Kawaoka, H Aikata… - Hepatology …, 2018 - Wiley Online Library
Aim As second‐line therapy, regorafenib has been shown to provide a survival benefit for
patients with hepatocellular carcinoma (HCC) who progress on sorafenib. In this …

Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: prospects for regorafenib therapy

T Terashima, T Yamashita, H Sunagozaka… - Hepatology …, 2018 - Wiley Online Library
Aim This study aimed to investigate liver functional reserves during sorafenib treatment for
advanced hepatocellular carcinoma (HCC), to identify predictive factors for maintaining …

[HTML][HTML] Skeletal muscle loss during multikinase inhibitors therapy: molecular pathways, clinical implications, and nutritional challenges

E Rinninella, M Cintoni, P Raoul, C Pozzo, A Strippoli… - Nutrients, 2020 - mdpi.com
In cancer patients, loss of muscle mass is significantly associated with low tolerability of
chemotherapy and poor survival. Despite the great strides in the treatment of cancer …