Therapeutic potential of gambogic acid, a caged xanthone, to target cancer

K Banik, C Harsha, D Bordoloi, BL Sailo, G Sethi… - Cancer letters, 2018 - Elsevier
Natural compounds have enormous biological and clinical activity against dreadful diseases
such as cancer, as well as cardiovascular and neurodegenerative disorders. In spite of the …

Gambogic acid: a shining natural compound to nanomedicine for cancer therapeutics

E Hatami, M Jaggi, SC Chauhan, MM Yallapu - Biochimica et Biophysica …, 2020 - Elsevier
Abstract The United States Food and Drug Administration has permitted number of
therapeutic agents for cancer treatment. Most of them are expensive and have some degree …

Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy

C Rajagopal, MB Lankadasari, JM Aranjani… - Pharmacological …, 2018 - Elsevier
Inflammation is one of the major causative factor of cancer and chronic inflammation is
involved in all the major steps of cancer initiation, progression metastasis and drug …

Therapeutic potential of traditional Chinese medicine for interstitial lung disease

YM Zhou, XR Dong, D Xu, J Tang, YL Cui - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Interstitial lung disease (ILD) is a chronic lung dysfunction
disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs …

Local delivery of gambogic acid to improve anti-tumor immunity against oral squamous cell carcinoma

X Chen, DR Chen, H Liu, L Yang, Y Zhang… - Journal of Controlled …, 2022 - Elsevier
Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of oral cavity malignancies.
However, despite significant advances in the last four decades, little improvement has been …

Influencing factors of falls among older adults in Chinese retirement institutions: A systematic review and meta-analysis

X Huang, Y Jiang, Y Liu, L Shen, J Pan, Y Zhang - PLoS one, 2023 - journals.plos.org
Background The incidence of falling has always been high among the elderly, and it was
easy to cause injuries to the elderly and seriously affect their quality of life. There were many …

A gambogic acid-loaded delivery system mediated by ultrasound-targeted microbubble destruction: A promising therapy method for malignant cerebral glioma

L Dong, N Li, X Wei, Y Wang, L Chang… - International Journal …, 2022 - Taylor & Francis
Background The blood–brain barrier (BBB) inhibits the delivery of macromolecular
chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects …

[HTML][HTML] Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway

W Fu, X Fang, L Wu, W Hu… - Korean J Physiol …, 2022 - synapse.koreamed.org
Sepsis-associated myocardial injury, an invertible myocardial depression, is a common
complication of sepsis. Neogambogic acid is an active compound in garcinia and exerts …

Gambogic acid induces HO-1 expression and cell apoptosis through p38 signaling in oral squamous cell carcinoma

SC Su, YT Chen, YH Hsieh, WE Yang… - The American journal …, 2022 - World Scientific
Gambogic acid (GA), a natural and bioactive compound from the gamboge resin, has been
reported to exhibit many oncostatic activities against several types of malignancies …

Investigations into the antibacterial effects and potential mechanism of gambogic acid and neogambogic acid

M Li, Y Chen, L Wang, C Lu, P Chen, Y Jin… - Frontiers in …, 2022 - frontiersin.org
The growing threat of antibiotic-resistant bacterial infections to public health necessitates the
development of novel antibacterial agents. Inhibiting bacterial cell wall synthesis has …