Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Simple Summary All cells are covered in a thick layer of sugar molecules known as glycans.
Changes to this sugar coat are common in cancer, and in particular cancer cells often …

Tumor cells exhibit striking changes in cell surface glycosylation as a consequence of
dysregulated glycosyltransferases and glycosidases. In particular, an increase in the …

The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors
(LXRs) were investigated. Molecular docking using crystal structures of the ligand binding …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

BACKGROUND: Cell migration is an essential process in organ homeostasis, in
inflammation, and also in metastasis, the main cause of death from cancer. The extracellular …

Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up
approach for re-engineering the molecular landscape of cell surfaces with spatially …

To better understand the molecular and structural basis underlying the interaction of vitamin
D3 hydroxyderivatives with AhR, molecular simulation was used to probe the binding of 1 …

N-glycosylations can regulate the adhesive function of integrins. Great variations in both the
number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin …