Non-apoptotic regulated cell death (RCD) is essential to maintain organismal homeostasis
and may be aberrantly activated during certain pathological states. Lipids are emerging as …

Cells depend on hugely diverse lipidomes for many functions. The actions and structural
integrity of the plasma membrane and most organelles also critically depend on membranes …

Solid tumors are characterized by global metabolic alterations which contribute to their
growth and progression. Altered gene expression profiles and plasma lipid composition …

Necroptosis is a form of regulated cell death that is linked to various human diseases.
Distinct membrane-related, thus lipid-dependent, alterations take place during necroptosis …

Treatment of triple-negative breast cancer (TNBC) is challenging because of its “COLD”
tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated …

Cellular replicative senescence, a state of permanent cell-cycle arrest, has been linked to
organismal aging, tissue repair and tumorigenesis. In this study, we comparatively …

Coessentiality mapping has been useful to systematically cluster genes into biological
pathways and identify gene functions,–. Here, using the debiased sparse partial correlation …

Osteosarcoma is the most common malignant bone tumor. In recent years, although a lot of
research in the mechanism of osteosarcoma development and metastasis had been done …

Simple Summary Existing chemotherapy treatments for breast cancer patients are high on
toxicity. There are very limited options available for triple-positive breast cancer (TPBC) …

Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves
ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human …