Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

The role of voltage-gated Ca2+ channels (VGCCs) in spontaneous miniature
neurotransmitter release is incompletely understood. We found that stochastic opening of …

The balance between fast synchronous and delayed asynchronous release of
neurotransmitters has a major role in defining computational properties of neuronal …

The mechanisms that enable synapses to achieve temporally and spatially precise signaling
at nano-scale while being fluid with the cytosol are poorly understood. Liquid-liquid phase …

Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still
poorly understood. We previously showed that GABAergic short-term plasticity is impaired in …

Action potentials invading the presynaptic terminal trigger discharge of docked synaptic
vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting …

The relationship between transmitter release evoked by action potentials and spontaneous
release has fascinated neuroscientists for half a century, and separate biological roles for …

CB1 cannabinoid receptors (CB1) are located at axon terminals and effectively control
synaptic communication and thereby circuit operation widespread in the CNS. Although it is …

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used class of
antidepressant drugs, but the cellular and molecular mechanisms by which their therapeutic …