Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s
yet the mechanisms of virally-mediated cellular transformation are still being revealed …

We have begun to define the human papillomavirus (HPV)-associated proteome for a subset
of the more than 120 HPV types that have been identified to date. Our approach uses a …

Carcinogen-induced oral cavity squamous cell carcinoma (OSCC) incurs significant
morbidity and mortality and constitutes a global health challenge. To gain further insight into …

Pim D, Banks L. Interaction of viral oncoproteins with cellular target molecules: infection with
high‐risk vs low‐risk human papillomaviruses. APMIS 2010; 118: 471–493. Persistent …

Breast cancer is the leading cause of cancer-related mortality in women worldwide, with an
estimated 1.7 million new cases and 522,000 deaths around the world in 2012 alone …

The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the
mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into …

Human papillomaviruses (HPVs) are small, DNA viruses that cause around 5% of all
cancers in humans, including almost all cervical cancer cases and a significant proportion of …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …