Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

Recent technological advances have stimulated efforts to bring personalized medicine into
practice. Yet, traditional application fields like therapeutic drug monitoring (TDM) have …

Biosensors used for medical diagnosis work by analyzing physiological fluids. Antibodies
have been frequently used as molecular recognition molecules for the specific binding of …

Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) with a narrow
therapeutic index is an increasingly popular tool for minimizing drug toxicity while …

Electrogenerated chemiluminescence (electrochemiluminescence, ECL) generates species
at electrode surfaces, which undergoes electron-transfer reactions and forms excited states …

Immunosuppressive drugs are administered to decrease immune system activity (eg of
patients undergoing solid organ transplant). Concentrations of immunosuppressive drugs …

More than 100 000 solid organ transplantations are performed every year worldwide.
Calcineurin (cyclosporine A, tacrolimus), serine/threonine kinase (sirolimus, everolimus) and …

Immunosuppressant drugs (ISDs) play a key role in short-term patient survival together with
very low acute allograft rejection rates in transplant recipients. Due to the narrow therapeutic …

Immunosuppressive drugs (ISDs) are primarily administered following solid organ transplant
or for treatment of a variety of autoimmune conditions. Their principal function is to suppress …

The transplantation of a solid organ is always followed by a lifelong immunosuppressive
therapy to guarantee the survival of the organ in the recipient. Immunosuppressive drugs …