[HTML][HTML] The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy

E Pavitra, J Kancharla, VK Gupta, K Prasad… - Biomedicine & …, 2023 - Elsevier
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

PR Dandawate, D Subramaniam, RA Jensen… - Seminars in cancer …, 2016 - Elsevier
Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment

RM Connolly, NK Nguyen, S Sukumar - Clinical Cancer Research, 2013 - AACR
Retinoids and their naturally metabolized and synthetic products (eg, all-trans retinoic acid,
13-cis retinoic acid, bexarotene) induce differentiation in various cell types. Retinoids exert …

Exploring the anti‐cancer potential of dietary phytochemicals for the patients with breast cancer: a comprehensive review

M Sohel, S Aktar, P Biswas, MA Amin… - Cancer …, 2023 - Wiley Online Library
Background The most common and deadly cancer in female is breast cancer (BC) and new
incidence and deaths related to this cancer are rising. Aims Several issues, that is, high cost …

Retinoic acid–related orphan receptor C regulates proliferation, glycolysis, and chemoresistance via the PD-L1/ITGB6/STAT3 signaling axis in bladder cancer

D Cao, Z Qi, Y Pang, H Li, H Xie, J Wu, Y Huang, Y Zhu… - Cancer research, 2019 - AACR
Retinoic acid–related orphan receptor C (RORC) is a member of the nuclear orphan
receptor family and performs critical regulatory functions in cell proliferation, metastasis, and …

The influence of peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cell tumorigenicity

S Yousefnia, S Momenzadeh, FS Forootan, K Ghaedi… - Gene, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor
superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on …

PPARs and tumor microenvironment: the emerging roles of the metabolic master regulators in tumor stromal–epithelial crosstalk and carcinogenesis

HS Cheng, YS Yip, EKY Lim, W Wahli, NS Tan - Cancers, 2021 - mdpi.com
Simple Summary The roles of peroxisome proliferator-activated receptors (PPARs) in
carcinogenesis are increasingly appreciated. With the growing interest in tumor stromal …

Aspirin suppresses the acquisition of chemoresistance in breast cancer by disrupting an NFκB–IL6 signaling axis responsible for the generation of cancer stem cells

S Saha, S Mukherjee, P Khan, K Kajal, M Mazumdar… - Cancer research, 2016 - AACR
Acquired chemoresistance has curtailed cancer survival since the dawn of chemotherapy.
Accumulating evidence suggests a major role for cancer stem cells (CSC) in …

Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice

S Squarzoni, E Schena, P Sabatelli, E Mattioli… - Aging cell, 2021 - Wiley Online Library
Hutchinson–Gilford progeria syndrome (HGPS) causes premature aging in children, with
adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells …

Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea

W Liang, L Huang, A Whelchel… - Proceedings of the …, 2023 - National Acad Sciences
Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an
important role in diabetic complications. However, the regulation of mitochondria function in …