Adult stem cells balance self-renewal and differentiation to build, maintain and repair
tissues. The role of signalling pathways and transcriptional networks in controlling stem cell …

The skin epidermis is continually influenced by a myriad of internal and external elements.
At its basal layer reside epidermal stem cells, which fuels epidermal renovation and hair …

Billions of cells are eliminated daily from our bodies,,–. Although macrophages and dendritic
cells are dedicated to migrating and engulfing dying cells and debris, many epithelial and …

Overconsumption of retinoic acid (RA) or its analogues/derivatives has been linked to
severe craniomaxillofacial malformations, such as cleft palate and midface hypoplasia. It has …

Androgenetic alopecia (AGA) is a non-fatal disease prevalent worldwide. However, mixed
efficacy has been observed among different therapies for hair regrowth in AGA patients …

Cutaneous wound healing is a slow process that often terminates with permanent scarring
while oral wounds, in contrast, regenerate after damage faster. Unique molecular networks …

Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial
roles in body axis orientation and tissue differentiation, including in the reproductive system …

Burn injuries often leave behind a “stasis zone”, a region of tissue critically important for
determining both the severity of the injury and the potential for recovery. To understand the …

Carotenoids are a diverse group of lipids produced by photosynthetic organisms, and
therefore, these compounds are major components of healthy diets. Carotenoids are among …

目的· 构建并验证可模拟维生素A 缺乏症(vitamin A deficiency, VAD) 导致的颅颌面骨畸形且
出生后可存活的模型小鼠. 方法· 运用Cre-LoxP 重组酶系统, 通过将OsxCre 与Rosa26dnRARα …