Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …

Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Despite decades of research, our understanding of the molecular interactions between
drugs and polymers in drug-loaded polymer micelles does not extend much beyond …

Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …

Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug
delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API …

The study of novel drug delivery systems represents one of the frontiers of the biomedical
research area. Multi-disciplinary scientific approaches combining traditional or engineered …

The bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be
improved via the formulation of an amorphous solid dispersion (ASD), where the API is …

A pair of popular thermodynamic models for pharmaceutical applications, namely, the
perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and the …