BMG Janssen, EHM Lempens, LLC Olijve, IK Voets… - Chemical …, 2013 - pubs.rsc.org
Antibody-based molecular recognition plays a dominant role in the life sciences ranging from applications in diagnostics and molecular imaging to targeted drug delivery and …
AW Drake, YN Abdiche, GA Papalia - Development of Antibody-Based …, 2018 - Springer
Abstract Development of therapeutic monoclonal antibodies requires rigorous measurements of the kinetic and thermodynamic binding properties of antibody–antigen …
Empirical data has shown that bivalent inhibitors can bind a given target protein significantly better than their monomeric counterparts. However, predicting the corresponding theoretical …
Simultaneous binding of a divalent ligand to two identical monovalent molecules is a widespread phenomenon in biology and chemistry. Here, we describe how two such …
Designed ligands that self-assemble noncovalently via an independent oligomerization domain have demonstrated enhancement in affinity for a variety of chemical and biological …
ET Mack, PJ Bracher… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
This critical review examines the thermodynamics of binding of bivalent antibodies (IgG and IgE) to soluble ligands with two or more binding moieties joined covalently (multivalent …
MA Tabrizi, SL Klakamp - Development of Antibody-Based Therapeutics …, 2018 - Springer
Application of an integrated approach for inclusion of pharmacology principles in drug development is a foundational step for effective modality design and selection of antibody …
LJ Cummings, R Perez-Castillejos, ET Mack - Bulletin of mathematical …, 2012 - Springer
This paper analyzes the biochemical equilibria between bivalent receptors, homo- bifunctional ligands, monovalent inhibitors, and their complexes. Such reaction schemes …
This paper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide ligands with different lengths (25 to 69 Å between the ends of the fully extended …