Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC)
are present in sensory neurons and vascular smooth muscle. PACAP infusion was found to …

VIP/PACAP has prominent growth effects on a number of common neoplasms, which
frequently overexpressed the three subtypes of their receptors. The increased …

Alzheimer's disease (AD) is a neurodegenerative pathology characterized by the presence
of senile plaques and neurofibrillary tangles, accompanied by synaptic and neuronal loss …

PACAP/VIP as well as their three classes of receptors are important in many physiological/
pathophysiological processes, some of which are identified in these studies using knockout …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its
role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP …

Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …

Ischemic stroke is the predominant cause of severe morbidity and mortality worldwide. Post-
stroke neuroinflammation has recently received increasing attention with the aim of …

Background and Purpose—Until now, except thrombolysis, the therapeutical strategies
targeting the acute phase of cerebral ischemia have been proven ineffective, and no …

Cognitive impairment is one of the major symptoms in most neurodegenerative disorders
such as Alzheimer's (AD), Parkinson (PD), and Huntington diseases (HD), affecting millions …