Timely detection of the pathophysiological changes and cognitive impairment caused by
Alzheimer's disease (AD) is increasingly pressing because of the advent of biomarker …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Importance Nationally representative data are critical for understanding the causes, costs,
and outcomes associated with dementia and mild cognitive impairment (MCI) in the US and …

Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Objective To determine the impact of lifestyle factors on life expectancy lived with and
without Alzheimer's dementia. Design Prospective cohort study. Setting The Chicago Health …

In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …

Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Circadian disruptions impact nearly all people with Alzheimer's disease (AD), emphasizing
both their potential role in pathology and the critical need to investigate the therapeutic …

There is emerging evidence that obstructive sleep apnea (OSA) is a risk factor for preclinical
Alzheimer's disease (AD). An American Thoracic Society workshop was convened that …