Pathophysiological mechanisms of genetic absence epilepsy in the rat

L Danober, C Deransart, A Depaulis, M Vergnes… - Progress in …, 1998 - Elsevier
Generalized non-convulsive absence seizures are characterized by the occurrence of
synchronous and bilateral spike and wave discharges (SWDs) on the electroencephalogram …

Basic mechanisms of generalized absence seizures

OC Snead III - Annals of Neurology: Official Journal of the …, 1995 - Wiley Online Library
Generalized absence seizures are neurophysiologically, pharmacologically, and
developmentally unique and comprise the primary seizure type in a number of different …

Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats

HKM Meeren, JPM Pijn… - Journal of …, 2002 - Soc Neuroscience
Absence seizures are the most pure form of generalized epilepsy. They are characterized in
the electroencephalogram by widespread bilaterally synchronous spike-wave discharges …

[图书][B] Models of seizures and epilepsy

A Pitkänen, AS Galanopoulou, SL Moshé - 2017 - books.google.com
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for
investigators who are searching for the most appropriate laboratory models to address key …

Dynamics of non-convulsive epileptic phenomena modeled by a bistable neuronal network

P Suffczynski, S Kalitzin, FHL Da Silva - Neuroscience, 2004 - Elsevier
It is currently believed that the mechanisms underlying spindle oscillations are related to
those that generate spike and wave (SW) discharges. The mechanisms of transition …

The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depressiony

K Sarkisova, G van Luijtelaar - Progress in Neuro-Psychopharmacology …, 2011 - Elsevier
A great number of clinical observations show a relationship between epilepsy and
depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic …

Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats

AML Coenen, W Drinkenburg, M Inoue… - Epilepsy research, 1992 - Elsevier
In this review, the main characteristics of genetic models of absence epilepsy, in particular
with respect to WAG/Rij rats, are presented. Genetic models are important and relevant …

Global and focal aspects of absence epilepsy: the contribution of genetic models

G van Luijtelaar, E Sitnikova - Neuroscience & Biobehavioral Reviews, 2006 - Elsevier
The cortico-reticular theory of absence epilepsy explains the origin of the bilateral
generalized spike-wave discharges (SWDs) characterizing absence seizures via a …

Spike-and-wave discharges of absence seizures as a transformation of sleep spindles: the continuing development of a hypothesis

GK Kostopoulos - Clinical Neurophysiology, 2000 - Elsevier
Objectives: This review aims to offer a critical account of recent scientific developments
relevant to the hypothesis which Pierre Gloor proposed in the 1970s for the generation of …

Methods of automated absence seizure detection, interference by stimulation, and possibilities for prediction in genetic absence models

G van Luijtelaar, A Lüttjohann, VV Makarov… - Journal of neuroscience …, 2016 - Elsevier
Background Genetic rat models for childhood absence epilepsy have become instrumental
in developing theories on the origin of absence epilepsy, the evaluation of new and …