Over the past decade, the application of magnetic resonance imaging (MRI) has increased,
and there is growing evidence to suggest that improvements in the accuracy of target …

Radiation therapy to the prostate involves increasingly sophisticated delivery techniques
and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per …

Background We aimed to assess the feasibility of a dose painting (DP) procedure, known as
simultaneous integrated boost intensity modulated radiation Therapy (SIB-IMRT), for treating …

Background Post‐radiotherapy locally recurrent prostate cancer (PCa) patients are
candidates for focal salvage treatment. Multiparametric MRI (mp‐MRI) is attractive for tumor …

Background Hypoxia dose painting is a radiotherapy technique to increase the dose to
hypoxic regions of the tumour. Still, the clinical effect relies on the reproducibility of the …

Background Escalation of prescribed dose in prostate cancer (PCa) radiotherapy enables
improvement in tumor control at the expense of increased toxicity. Opportunities for …

Background In prostate radiation therapy, recent studies have indicated a benefit in
increasing the dose to intraprostatic lesions (IPL) compared with standard whole gland …

Background and purpose Glioblastoma (GBM) patients have a dismal prognosis. Tumours
typically recur within months of surgical resection and post-operative chemoradiation …

Aims This study aimed to develop a framework for optimising prostate intensity-modulated
radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric …

Intro. Current radiation therapy (RT) planning guidelines handle uncertainties in RT using
geometric margins. This approach is simple to use but oversimplifies complex underlying …