Steroid hormones regulate essential physiological processes and inadequate levels are
associated with various pathological conditions. Consequently, the process of steroid …

Cell differentiation and acquisition of specialized functions are inherent steps in events that
lead to normal tissue development and function. These processes require accurate …

Platelets are anucleated blood elements highly potent at generating extracellular vesicles
(EVs) called microparticles (MPs). Whereas EVs are accepted as an important means of …

Disorders (or differences) of sex development (DSD) are a heterogeneous group of
congenital conditions with variations in chromosomal, gonadal, or anatomical sex. Impaired …

Progressive increases in the incidence of male reproductive disorders inclusive of
hypospadias, cryptorchidism, poor semen quality, and testicular germ cell cancer (TGCC) …

The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …

Abstract NR2F2 encodes COUP-TFII, an orphan nuclear receptor required for the
development of the steroidogenic lineages of the murine fetal testes and ovaries …

Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which
is produced and secreted by the fetal Leydig cells in the testes only. It appears to be …

In brief The insulin-like 3 (INSL3) hormone produced by Leydig cells is essential for proper
male sex differentiation, but the regulation of Insl3 expression remains poorly understood …

Leydig cells, located within the interstitial compartment of the testis, are major contributors of
androgen synthesis and secretion, which play an important role in testis development …