Neuroinflammation and Epilepsy: From Pathophysiology to Therapies Based on Repurposing Drugs

P Sanz, T Rubio, MA Garcia-Gimeno - International Journal of Molecular …, 2024 - mdpi.com
Neuroinflammation and epilepsy are different pathologies, but, in some cases, they are so
closely related that the activation of one of the pathologies leads to the development of the …

Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic …

MJ Goodfellow, A Borcar, JL Proctor, T Greco… - Experimental …, 2020 - Elsevier
Mitochondria are both a primary source of reactive oxygen species (ROS) and a sensitive
target of oxidative stress; damage to mitochondria can result in bioenergetic dysfunction and …

Selenium nanoparticles pre-treatment reverse behavioral, oxidative damage, neuronal loss and neurochemical alterations in pentylenetetrazole-induced epileptic …

X Yuan, Z Fu, P Ji, L Guo, AO Al-Ghamdy… - International Journal …, 2020 - Taylor & Francis
Introduction Epilepsy is a chronic neurological condition characterized by behavioral,
molecular, and neurochemical alterations. Current antiepileptic drugs are associated with …

Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury

J Zhang, M Zhang, WH Zhang, QM Zhu, J Ning, XK Huo… - Phytomedicine, 2022 - Elsevier
Background Acute lung injury (ALI) is a life-threatening lung disease and characterized by
pulmonary edema and atelectasis. Inula japonica Thunb. is a commonly used traditional …

Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling

Z Kazmi, S Zeeshan, A Khan, S Malik, A Shehzad… - Neurotoxicology, 2020 - Elsevier
Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent
seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) …

Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation

RM El-Sayed, MN Fawzy, HF Zaki… - International …, 2023 - Elsevier
Recurrent seizures characterize epilepsy, a complicated and multifaceted neurological
disease. Several neurological alterations, such as cell death and the growth of gorse fibers …

Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

G Bai, Y Qiao, PC Lo, L Song, Y Yang, L Duan… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Jiao-Tai-Wan (JTW) is a very famous traditional
Chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety …

Applicability of hiPSC-Derived Neuronal Cocultures and Rodent Primary Cortical Cultures for In Vitro Seizure Liability Assessment

AM Tukker, FMJ Wijnolts, A de Groot… - Toxicological …, 2020 - academic.oup.com
Seizures are life-threatening adverse drug reactions which are investigated late in drug
development using rodent models. Consequently, if seizures are detected, a lot of time …

Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice

G Casili, M Lanza, A Filippone, M Campolo… - Journal of …, 2020 - Springer
Background Oxidative stress and inflammatory pathways are involved in migraine and
endogenous antioxidant defense system has a role in the prevention of hyperalgesia in …

Antioxidant dimethyl fumarate temporarily but not chronically improves intracortical microelectrode performance

GF Hoeferlin, T Bajwa, H Olivares, J Zhang… - Micromachines, 2023 - mdpi.com
Intracortical microelectrode arrays (MEAs) can be used in a range of applications, from basic
neuroscience research to providing an intimate interface with the brain as part of a brain …