Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Dendritic cells (DC) are professional antigen presenting cells comprising a variety of
subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the …

The efficiency of a vaccine largely depends on the appropriate targeting of the innate
immune system, mainly through prolonged delivery of antigens and immunomodulatory …

Upon infection, adaptive immune responses play catch-up with rapidly replicating
pathogens. While mechanisms for efficient humoral responses to lymph-borne antigens …

The skin is a highly complex organ interspersed with a variety of smaller organ-like
structures and a plethora of cell types that together perform essential functions such as …

Infection-induced inflammatory reactions involve a strong increase in dendritic cells (DCs) at
the infection site and draining lymph nodes (dLNs). Whether inflammatory DCs are recruited …

Mycobacterium tuberculosis (Mtb) is thought to reside in macrophages, although infected
dendritic cells (DCs) have been observed. Thus, although cellular associations have been …

We examine the role of dendritic cells subsets in immunity to peripheral infections, with
emphasis on the differences in the regulation of primary and secondary T cell responses to …

Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin
and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is …

The role of different DC subsets in priming and maintenance of immunity against
Leishmania major (L. major) infection is debated. The transcription factor basic leucine …