A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

Autism Spectrum Disorder (ASD) demonstrates high heritability and familial clustering, yet
the genetic causes remain only partially understood as a result of extensive clinical and …

Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

About 50years after Harris's first demonstration of its existence, GnRH has strongly
stimulated the interest and imagination of scientists, resulting in a high number of studies in …

p53 Reactivation and induction of massive apoptosis (PRIMA-1) is a small-molecule
compound that reactivates mutant p53, restoring its normal tumor suppressor function …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Idiopathic hypogonadotropic hypogonadism (IHH) is defined by absent or incomplete
puberty and characterised biochemically by low levels of sex steroids, with low or …