Developments in lncRNA drug discovery: where are we heading?

I Blokhin, O Khorkova, J Hsiao… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: The central dogma of molecular biology, which states that the only role of long
RNA transcripts is to convey information from gene to protein, was brought into question in …

A review on the expression pattern of non-coding RNAs in patients with schizophrenia: With a special focus on peripheral blood as a source of expression analysis

S Ghafouri-Fard, R Eghtedarian, M Taheri… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia is a destructive neuropsychiatric disease with a median prevalence of 4.0 per
1,000 during the whole life. Genome-wide association studies have shown the role of copy …

[HTML][HTML] Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells

IA Akkouh, T Ueland, L Hansson, E Inderhaug… - Brain, behavior, and …, 2020 - Elsevier
Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its
pathophysiology is mainly unknown, dysregulated immune activation and inflammation have …

Protective effect of surfactin on copper sulfate‐induced inflammation, oxidative stress, and hepatic injury in zebrafish

Y Wang, J Tian, F Shi, X Li, Z Hu… - Microbiology and …, 2021 - Wiley Online Library
Surfactin, an antibacterial peptide, produced by various Bacillus subtilis strains, have broad‐
spectrum antibacterial and immune‐enhancing functions. In this study, we investigated the …

Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish

J Li, Y Zhang, L Han, Q Tian, Q He, X Wang… - Fish & shellfish …, 2018 - Elsevier
Marsdenia tenacissima exhibits biological activity with heat-clearing and detoxifying
properties, relieving coughs and asthma and exerting anticancer and anti-HIV effects …

The machine learning algorithm for the diagnosis of schizophrenia on the basis of gene expression in peripheral blood

L Zhu, X Wu, B Xu, Z Zhao, J Yang, J Long, L Su - Neuroscience letters, 2021 - Elsevier
Background Schizophrenia (SCZ) is a highly heritable mental disorder with a substantial
disease burden. Machine learning (ML) method can be used to identify individuals with SCZ …

The relationship between neuroimmunity and bipolar disorder: mechanism and translational application

Z Niu, L Yang, X Wu, Y Zhu, J Chen, Y Fang - Neuroscience bulletin, 2019 - Springer
Neuroimmune system may be involved in the pathological process of bipolar disorder (BD),
but the essential association is not fully understood. Accumulating evidence has shown that …

Genetic variability of serotonin pathway associated with schizophrenia onset, progression, and treatment

K Hrovatin, T Kunej, V Dolžan - American Journal of Medical …, 2020 - Wiley Online Library
Schizophrenia (SZ) onset and treatment outcome have important genetic components,
however individual genes do not have strong effects on SZ phenotype. Therefore, it is …

A comprehensive review on the role of non-coding RNAs in the pathophysiology of bipolar disorder

S Ghafouri-Fard, E Badrlou, M Taheri… - International Journal of …, 2021 - mdpi.com
Aim: Bipolar disorder is a multifactorial disorder being linked with dysregulation of several
genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder …

Effects of adjunctive inflammatory modulation on IL-1β in treatment resistant bipolar depression

S Murata, M Murphy, D Hoppensteadt, J Fareed… - Brain, behavior, and …, 2020 - Elsevier
Background Adjunctive inflammatory modulation improved remission rates in treatment-
resistant bipolar depression (TRBDD), but reliable biomarkers must be established to …