As the primary barrier between an organism and its environment, epithelial cells are well-
positioned to regulate tolerance while preserving immunity against pathogens. Class II …

The immune system's correct functioning requires a sophisticated balance between
responses to continuous microbial challenges and tolerance to harmless antigens, such as …

Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …

Air pollution and climate change are potential drivers for the increasing burden of allergic
diseases. The molecular mechanisms by which air pollutants and climate parameters may …

Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

The introduction of immune checkpoint inhibitors in cancer treatment highlights the negative
regulation of anti-tumor immunity, such as effector T-cell exhaustion in the tumor …

BACKGROUND: Asthma is defined as a chronic inflammatory disease of the airways;
however, the underlying physiologic and immunologic processes are not fully understood …

Recent discoveries have led to the identification of a novel group of immune cells, the innate
lymphoid cells (ILCs). The members of this group are divided into three subpopulations …

Mechanisms linking intestinal bacteria and neurodegenerative diseases such as
Alzheimer's disease (AD) are still unclear. We hypothesized that intestinal dysbiosis might …