The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …

Tremendous strides have been made in the molecular and cytogenetic classification of
acute lymphoblastic leukemia based on gene expression profiling data, leading to an …

Genomic characterization is an essential part of the clinical management of hematological
malignancies for diagnostic, prognostic and therapeutic purposes. Although CBA and FISH …

RNA-sequencing (RNA-seq) efforts in acute lymphoblastic leukaemia (ALL) have identified
numerous prognostically significant genomic alterations which can guide diagnostic risk …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a common
subtype of B-lineage acute lymphoblastic leukemia (B-ALL) with increasing frequency …

B-acute lymphoblastic leukemia (B-ALL) consists of dozens of subtypes defined by distinct
gene expression profiles (GEP) and various genetic lesions. With the application of …

Acute lymphoblastic leukemia (ALL) can be classified into different subgroups based on
recurrent genetic alterations. Here, targeted RNA sequencing was used to identify the novel …

Recognition of aberrant gene isoforms due to DNA events can impact risk stratification and
molecular classification of hematolymphoid tumors. In myelodysplastic syndromes, KMT2A …

Studies have shown the power of transcriptome sequencing [RNA sequencing (RNA-Seq)]
in identifying known and novel oncogenic drivers and molecular subtypes of B-acute …

Lymphoblastic leukemia/lymphoma (ALL/LBL), especially certain subtypes, continues to
confer morbidity and mortality despite significant therapeutic advances. The pathologic …