Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …
showed a variety of pharmacological properties, and its derivatives propose a high degree …
Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review
The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …
classes of antibiotics agents. The development of antibacterial agents with the novel method …
Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety
Abstract Development of new antimicrobial agents is a good solution to overcome drug-
resistance problems. In this context, new functionalized thiophene, acrylamide …
resistance problems. In this context, new functionalized thiophene, acrylamide …
2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry
K Bozorov, LF Nie, J Zhao, HA Aisa - European journal of medicinal …, 2017 - Elsevier
Aminothiophenes are important five-membered heterocyclic building blocks in organic
synthesis, and the chemistry of these small molecules is still developing based on the …
synthesis, and the chemistry of these small molecules is still developing based on the …
Binding mode analysis, dynamic simulation and binding free energy calculations of the MurF ligase from Acinetobacter baumannii
MurF ligase catalyzes the final cytoplasmic step of bacterial peptidoglycan biosynthesis and,
as such, is a validated target for therapeutic intervention. Herein, we performed molecular …
as such, is a validated target for therapeutic intervention. Herein, we performed molecular …
Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F
The widespread emergence of resistant bacterial strains is becoming a serious threat to
public health. This thus signifies the need for the development of new antibacterial agents …
public health. This thus signifies the need for the development of new antibacterial agents …
Thiophene‐containing compounds with antimicrobial activity
G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents
J Hwang, X Qiu, L Borgelt, N Haacke, L Kanis… - Bioorganic & Medicinal …, 2022 - Elsevier
Aminothiophene is a scaffold that is widely present in drugs and biologically active small
molecules as chemical probes. In this study, 43 compounds sharing a 2-aminothiophenone …
molecules as chemical probes. In this study, 43 compounds sharing a 2-aminothiophenone …
Antibiotics and Antibiotic Resistance—Mur Ligases as an Antibacterial Target
V Hervin, V Roy, LA Agrofoglio - Molecules, 2023 - mdpi.com
The emergence of Multidrug Resistance (MDR) strains of bacteria has accelerated the
search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway …
search for new antibacterials. The specific bacterial peptidoglycan biosynthetic pathway …
Overcoming Klebsiella pneumoniae antibiotic resistance: new insights into mechanisms and drug discovery
TXN Huy - Beni-Suef University Journal of Basic and Applied …, 2024 - Springer
Background Due to antibiotic overuse, numerous organisms have evolved multidrug
resistance, a global health crisis. Klebsiella pneumoniae (K. pneumoniae) causes …
resistance, a global health crisis. Klebsiella pneumoniae (K. pneumoniae) causes …