Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

K Andrysiak, J Stępniewski, J Dulak - Pflügers Archiv-European Journal of …, 2021 - Springer
Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

Clinical translation of pluripotent stem cell therapies: challenges and considerations

M Desgres, P Menasche - Cell Stem Cell, 2019 - cell.com
Although the clinical outcomes of cell therapy trials have not met initial expectations,
emerging evidence suggests that injury-mediated tissue damage might benefit from the …

Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems

M Prondzynski, P Berkson, MA Trembley… - Nature …, 2024 - nature.com
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac
disease modeling and regeneration. Challenges with quality, inter-batch consistency …

Fatty acid-treated induced pluripotent stem cell-derived human cardiomyocytes exhibit adult cardiomyocyte-like energy metabolism phenotypes

Y Horikoshi, Y Yan, M Terashvili, C Wells, H Horikoshi… - Cells, 2019 - mdpi.com
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs)(iPSC-CMs) are
a promising cell source for myocardial regeneration, disease modeling and drug …

Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip

J Veldhuizen, J Cutts, DA Brafman, RQ Migrino… - Biomaterials, 2020 - Elsevier
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the
leading cause of mortality worldwide. Considerable research into human pluripotent stem …

Recent advancements in cardiovascular bioprinting and bioprinted cardiac constructs

H Budharaju, A Subramanian, S Sethuraman - Biomaterials Science, 2021 - pubs.rsc.org
Cardiovascular diseases (CVDs) are the leading causes of mortality globally that demand
the application of tissue engineering strategies to repair damaged tissues. Conventional …

Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation

N Harlaar, SO Dekker, J Zhang, RR Snabel… - Nature Biomedical …, 2022 - nature.com
The lack of a scalable and robust source of well-differentiated human atrial myocytes
constrains the development of in vitro models of atrial fibrillation (AF). Here we show that …

Silk‐based biomaterials for cardiac tissue engineering

Y Song, H Wang, F Yue, Q Lv, B Cai… - Advanced …, 2020 - Wiley Online Library
Cardiovascular diseases are one of the leading causes of death globally. Among various
cardiovascular diseases, myocardial infarction is an important one. Compared with …

Recent progress in stem cell modification for cardiac regeneration

H Lemcke, N Voronina, G Steinhoff… - Stem Cells …, 2018 - Wiley Online Library
During the past decades, stem cell‐based therapy has acquired a promising role in
regenerative medicine. The application of novel cell therapeutics for the treatment of …

Advances in cardiac tissue engineering

T Kitsuka, F Takahashi, J Reinhardt, T Watanabe… - Bioengineering, 2022 - mdpi.com
Tissue engineering has paved the way for the development of artificial human cardiac
muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial …