An overview of pre‐ribosomal RNA processing in eukaryotes

AK Henras, C Plisson‐Chastang… - Wiley …, 2015 - Wiley Online Library
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Architecture of the yeast small subunit processome

M Chaker-Margot, J Barandun, M Hunziker, S Klinge - Science, 2017 - science.org
INTRODUCTION The eukaryotic ribosome is assembled through an intricate process that
involves in excess of 250 nonribosomal proteins and small nucleolar RNAs (snoRNAs) …

Genetics animates structure: leveraging genetic interactions to study the dynamics of ribosome biogenesis

JJ Black, AW Johnson - Current Genetics, 2021 - Springer
The assembly of eukaryotic ribosomes follows an assembly line-like pathway in which
numerous trans-acting biogenesis factors act on discrete pre-ribosomal intermediates to …

Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development

C Zhao, V Andreeva, Y Gibert, M LaBonty… - PLoS …, 2014 - journals.plos.org
During vertebrate craniofacial development, neural crest cells (NCCs) contribute to most of
the craniofacial pharyngeal skeleton. Defects in NCC specification, migration and …

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae

JJ Black, R Sardana, EW Elmir, AW Johnson - PLoS Genetics, 2020 - journals.plos.org
The first metastable assembly intermediate of the eukaryotic ribosomal small subunit (SSU)
is the SSU Processome, a large complex of RNA and protein factors that is thought to …

Sas10 controls ribosome biogenesis by stabilizing Mpp10 and delivering the Mpp10–Imp3–Imp4 complex to nucleolus

S Zhao, Y Chen, F Chen, D Huang, H Shi… - Nucleic Acids …, 2019 - academic.oup.com
Mpp10 forms a complex with Imp3 and Imp4 that serves as a core component of the
ribosomal small subunit (SSU) processome. Mpp10 also interacts with the nucleolar protein …

Crucial role of the Rcl1p–Bms1p interaction for yeast pre-ribosomal RNA processing

A Delprato, YA Kadri, N Pérébaskine… - Nucleic acids …, 2014 - academic.oup.com
The essential Rcl1p and Bms1p proteins form a complex required for 40S ribosomal subunit
maturation. Bms1p is a GTPase and Rcl1p has been proposed to catalyse the …

Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae

K Shimoji, J Jakovljevic, K Tsuchihashi… - Nucleic acids …, 2012 - academic.oup.com
The yeast protein Ebp2 is required for early steps in production of 60S ribosomal subunits.
To search for cofactors with which Ebp2 functions, or substrates on which it acts, we …

Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA

G Clerget, V Bourguignon-Igel… - Nucleic acids …, 2020 - academic.oup.com
U3 snoRNA and the associated Rrp9/U3-55K protein are essential for 18S rRNA production
by the SSU-processome complex. U3 and Rrp9 are required for early pre-rRNA cleavages …

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing

EA Champion, BH Lane, ME Jackrel… - … and cellular biology, 2008 - Am Soc Microbiol
The small subunit (SSU) processome is a ribosome biogenesis intermediate that assembles
from its subcomplexes onto the pre-18S rRNA with yet unknown order and structure. Here …