Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Targeting cancer cells with high specificity is one of the most essential yet challenging goals
of tumor therapy. Because different surface receptors, transporters, and integrins are …

Nitroxide-mediated polymerization (NMP) is a reversible-deactivation radical polymerization
technique (RDRP) that facilitates the synthesis of well-defined and complex macromolecular …

In recent years, polymer nanoassemblies have played an important role in the
biopharmaceuticals field. Polymers that form different molecular architectures during a self …

In vivo fluorescence imaging provides vital information required for biomedical research in
living animals, and as such plays an essential role in disease assessment. Unfortunately …

Radical ring-opening polymerization (rROP) has received renewed attention to incorporate
cleavable linkages into the backbones of vinyl polymers, especially from cyclic ketene …

Enzyme-activatable anticancer prodrugs are modified medications that are composed of an
anticancer drug, cleavable linker, and functional moiety. The purpose of such a prodrug …

Rationale: The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain.
Sonopermeation, which relies on the combination of ultrasound and microbubbles, has …

Background: Docetaxel and doxorubicin combination has been widely used in anaplastic
thyroid cancer/ATC treatment but often results in serious adverse effects and drug …

Despite their great versatility and ease of functionalization, most polymer-based
nanocarriers intended for use in drug delivery often face serious limitations that can prevent …