Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms

A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Iron metabolism and immune regulation

S Ni, Y Yuan, Y Kuang, X Li - Frontiers in immunology, 2022 - frontiersin.org
Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly
controlled in the body, disturbance of iron homeostasis under certain type of condition leads …

[HTML][HTML] A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

Z Li, T Zhao, J Ding, H Gu, Q Wang, Y Wang, D Zhang… - Bioactive materials, 2023 - Elsevier
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by
complicated inflammation-related pathological processes, such as excessive reactive …

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

S Faissner, JR Plemel, R Gold, VW Yong - Nature reviews drug …, 2019 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …

Immune cell regulation of glia during CNS injury and disease

AD Greenhalgh, S David, FC Bennett - Nature Reviews Neuroscience, 2020 - nature.com
Glial cells are abundant in the CNS and are essential for brain development and
homeostasis. These cells also regulate tissue recovery after injury and their dysfunction is a …

The biology of regeneration failure and success after spinal cord injury

AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

[HTML][HTML] Functional nanomaterials in peripheral nerve regeneration: scaffold design, chemical principles and microenvironmental remodeling

Y Qian, H Lin, Z Yan, J Shi, C Fan - Materials Today, 2021 - Elsevier
Neuronal microenvironment imbalance is associated with successive and irreversible
pathophysiological changes and insufficient functional restoration after peripheral nerve …