Hypoglycemia in diabetes

PE Cryer, SN Davis, H Shamoon - Diabetes care, 2003 - Am Diabetes Assoc
Iatrogenic hypoglycemia causes recurrent morbidity in most people with type 1 diabetes and
many with type 2 diabetes, and it is sometimes fatal. The barrier of hypoglycemia generally …

[HTML][HTML] Mechanisms of hypoglycemia unawareness and implications in diabetic patients

I Martín-Timón, FJ del Cañizo-Gómez - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
Hypoglycemia unawareness (HU) is defined at the onset of neuroglycopenia before the
appearance of autonomic warning symptoms. It is a major limitation to achieving tight …

Pharmacologic glycemic management of type 2 diabetes in adults

L Lipscombe, G Booth, S Butalia, K Dasgupta… - Canadian journal of …, 2018 - Elsevier
People with type 2 diabetes form a heterogeneous group. Consequently, treatment
regimens and therapeutic targets should be individualized. The treatment of type 2 diabetes …

The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients

MC Riddle, J Rosenstock, J Gerich… - Diabetes …, 2003 - Am Diabetes Assoc
OBJECTIVE—To compare the abilities and associated hypoglycemia risks of insulin
glargine and human NPH insulin added to oral therapy of type 2 diabetes to achieve 7 …

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+ SU): a randomised …

D Russell-Jones, A Vaag, O Schmitz, BK Sethi, N Lalic… - Diabetologia, 2009 - Springer
Aims/hypothesis The aim of the study was to compare the efficacy and safety of liraglutide in
type 2 diabetes mellitus vs placebo and insulin glargine (A21Gly, B31Arg, B32Arg human …

Insulin analogues

IB Hirsch - New England Journal of Medicine, 2005 - Mass Medical Soc
In the 1990s, the value of glycemic control in the management of diabetes became
incontrovertible. The interest in producing insulin formulations that are safer than previous …

Factors affecting the absorption of subcutaneously administered insulin: effect on variability

AKJ Gradel, T Porsgaard, J Lykkesfeldt… - Journal of diabetes …, 2018 - Wiley Online Library
Variability in the effect of subcutaneously administered insulin represents a major challenge
in insulin therapy where precise dosing is required in order to achieve targeted glucose …

The Diabetes Treatment Satisfaction Questionnaire change version (DTSQc) evaluated in insulin glargine trials shows greater responsiveness to improvements than …

C Bradley, R Plowright, J Stewart, J Valentine… - Health and quality of life …, 2007 - Springer
Background The results of using status measures to identify any changes in treatment
satisfaction strongly suggest a need for specific change instruments designed to overcome …

Childhood obesity and type 2 diabetes mellitus

TS Hannon, G Rao, SA Arslanian - Pediatrics, 2005 - publications.aap.org
Until recently, the majority of cases of diabetes mellitus among children and adolescents
were immune-mediated type 1a diabetes. Obesity has led to a dramatic increase in the …

[PDF][PDF] Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities

NN Zammitt, BM Frier - Diabetes care, 2005 - Citeseer
The importance of strict glycemic control to limit the risk of diabetic vascular complications is
indisputable, but many barriers obstruct its attainment. Hypoglycemia is recognized to be a …