The amount of positive cocaine results in an urban emergency department are staggering.
The ages of use are becoming more common in older age groups. Most of these patients …

New groups of synthetic “designer drugs” have increased in popularity over the past several
years. These products mimic the euphoric effects of other well-known illicit drugs but are …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Cocaine is known to activate microglia both in vitro and in vivo. High expression of microglial
Toll-like receptors (TLRs) and their downstream signal transducers play critical roles in …

Background Neuroinflammation associated with advanced human immunodeficiency virus
(HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has …

MicroRNA-124 (miR-124), a brain-enriched microRNA, is known to regulate microglial
quiescence. Psychostimulants such as cocaine have been shown to activate microglia by …

Excited delirium (ED) syndrome is a serious medical condition associated with acute onset
of agitated violent behavior that often culminates in a sudden unexplained death. While the …

Cocaine is known to induce inflammation, thereby contributing in part, to the pathogenesis of
neurodegeneration. A recent study from our lab has revealed a link between …

Background By performing identical studies in humans and rats, we attempted to distinguish
vulnerability factors for addiction from neurobiological effects of chronic drug exposure. We …

Excited (or agitated) delirium is characterized by agitation, aggression, acute distress and
sudden death, often in the pre-hospital care setting. It is typically associated with the use of …