Circadian clock desynchronization and insulin resistance

F Catalano, F De Vito, V Cassano… - International Journal of …, 2022 - mdpi.com
The circadian rhythm regulates biological processes that occur within 24 h in living
organisms. It plays a fundamental role in maintaining biological functions and responds to …

Is obstructive sleep apnea a circadian rhythm disorder?

J Šmon, E Kočar, T Pintar… - Journal of sleep …, 2023 - Wiley Online Library
Obstructive sleep apnea is the most common sleep‐related breathing disorder worldwide
and remains underdiagnosed. Its multiple associated comorbidities contribute to a …

Circadian mechanisms in adipose tissue bioenergetics and plasticity

C Hepler, J Bass - Genes & Development, 2023 - genesdev.cshlp.org
The circadian clock plays an essential role in coordinating feeding and metabolic rhythms
with the light/dark cycle. Disruption of clocks is associated with increased adiposity and …

[HTML][HTML] The biological clock of liver metabolism in metabolic dysfunction-associated steatohepatitis progression to hepatocellular carcinoma

PK Rajan, UAS Udoh, R Finley, SV Pierre, J Sanabria - Biomedicines, 2024 - mdpi.com
Circadian rhythms are endogenous behavioral or physiological cycles that are driven by a
daily biological clock that persists in the absence of geophysical or environmental temporal …

Volumetric compression for engineering living systems

Y Li, M Guo - Nature Reviews Bioengineering, 2024 - nature.com
Life, as a dense manifestation of soft matter, undergoes changes in water content,
biomacromolecular concentrations, condensation and crowding due to volumetric …

Clock gene Per2 modulates epidermal tissue repair in vivo

VQ Yujra, EJD Silveira, DA Ribeiro… - Journal of Cellular …, 2024 - Wiley Online Library
Wound healing can be influenced by genes that control the circadian cycle, including Per2
and BMAL1, which coordinate the functions of several organs, including the skin. The aim of …

The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

A Azzi, Z Tao, Y Sun, H Erb, C Guarino, X Wu - Iscience, 2023 - cell.com
Circadian clock controls daily behavior and physiology. The activity of various signaling
pathways affects clock gene expression. Here, we show that the core circadian clock gene …

Transcription repression of Cry2 via Per2 interaction promotes adipogenesis

W Li, X Xiong, T Kiperman, K Ma - Molecular and Cellular Biology, 2023 - Taylor & Francis
The circadian clock is driven by a transcriptional-translational feedback loop, and
cryptochrome 2 (CRY2) represses CLOCK/BMAL1-induced transcription activation. Despite …

The emergence of circadian timekeeping in the intestine

K Parasram, A Zuccato, M Shin, R Willms… - Nature …, 2024 - nature.com
The circadian clock is a molecular timekeeper, present from cyanobacteria to mammals, that
coordinates internal physiology with the external environment. The clock has a 24-h period …

Early enforcement of cell identity by a functional component of the terminally differentiated state

Z Bahrami-Nejad, ZB Zhang, S Tholen, S Sharma… - PLoS …, 2022 - journals.plos.org
How progenitor cells can attain a distinct differentiated cell identity is a challenging problem
given the fluctuating signaling environment in which cells exist and that critical transcription …