Gait impairments are among the most common and disabling symptoms of Parkinson's
disease. Nonetheless, gait is not routinely assessed quantitatively but is described in …

Importance Patients with Parkinson disease can use a wide variety of strategies to
compensate for their gait impairments. Examples include walking while rhythmically …

Diverse but complementary methodologies are required to uncover the complex
determinants and pathophysiology of freezing of gait. To develop future therapeutic …

The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …

Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar
microstructural indices of the brain white matter. Lower than normal fractional anisotropy as …

Freezing of gait (FOG) is a common and disabling symptom in people with Parkinson's
Disease (PwPD). Although cognition is thought to be worse in PwPD who freeze, a …

Freezing of gait (FOG) is a paroxysmal gait disorder that often occurs at advanced stages of
Parkinson's disease (PD). FOG consists of abrupt walking interruption and severe difficulty in …

Structural and functional connectivity abnormalities have been reported previously in
multiple sclerosis. However, little is known about how each modality evolution relates to the …

Impaired locomotion is a frequent and major source of disability in patients with neurological
conditions. Different neuroimaging methods have been used to understand the brain …

A recent Scientific Panel Discussion led by the Scientific Issues Committee of the
International Parkinson and Movement Disorder Society has concluded that a “systems …