Objective. Neuromodulation of visceral nerves is being intensively studied for treating a wide
range of conditions, but effective translation requires increasing the efficacy and …

Hyperalgesic priming, a form of neuroplasticity induced by inflammatory mediators, in
peripheral nociceptors enhances the magnitude and duration of action potential (AP) firing …

The King Baboon spider, Pelinobius muticus, is a burrowing African tarantula. Its impressive
size and appealing coloration are tempered by reports describing severe localized pain …

Extracellular ATP and serotonin (5-HT) are powerful triggers of nociceptive firing in the
meninges, a process supporting headache and whose cellular mechanisms are …

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, painful side effect
which arises due to a number of chemotherapy agents. CIPN can have a prolonged effect on …

The back-propagation of an action potential (AP) from the axon/soma to the dendrites plays
a central role in dendritic integration. This process involves an intricate orchestration of …

Objective Nav1. 8 expression is restricted to sensory neurons; it was hypothesized that
aberrant expression and function of this channel at the site of injury contributed to …

Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the
SCN1A gene that encodes the α1 subunit of voltage-gated NaV1. 1 sodium channels. The …

Merkel cells combine with Aβ afferents, producing slowly adapting type 1 (SA1) responses to
mechanical stimuli. However, how Merkel cells transduce mechanical stimuli into neural …

Sensory neurons embedded in muscle tissue that initiate pain sensations, ie, nociceptors,
are temporarily sensitized by inflammatory mediators during musculoskeletal trauma. These …