Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in
patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades …

Abstract The Million Veteran Program (MVP) was established in 2011 as a national research
initiative to determine how genetic variation influences the health of US military veterans …

Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and
environmental factors. Ninety-seven genetic risk loci have been identified to date, but the …

Atrial fibrillation (AF) affects more than 33 million individuals worldwide and has a complex
heritability. We conducted the largest meta-analysis of genome-wide association studies …

Importance Recent guidelines endorse using history of menopause before age 40 years to
refine atherosclerotic cardiovascular disease risk assessments among middle-aged women …

Aims While most patients with myocardial infarction (MI) have underlying coronary
atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought …

Genome-wide association studies (GWAS) have identified thousands of genomic regions
affecting complex diseases. The next challenge is to elucidate the causal genes and …