Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

For electrons to continuously enter and flow through the mitochondrial electron transport
chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known …

Reactive oxygen species (ROS) are series of chemical products originated from one or
several electron reductions of oxygen. ROS are involved in physiology and disease and can …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to
be the main cause of aging and age-related diseases including cancer, diabetes and …

The brain and behavior are under energetic constraints, limited by mitochondrial energy
transformation capacity. However, the mitochondria-behavior relationship has not been …

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment.
Mitochondria are major consumers of oxygen and a potential source of reactive oxygen …

Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain
and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …