The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
Hybrid quantum-classical algorithms and quantum error mitigation
Quantum computers can exploit a Hilbert space whose dimension increases exponentially
with the number of qubits. In experiment, quantum supremacy has recently been achieved …
with the number of qubits. In experiment, quantum supremacy has recently been achieved …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
Boosting zinc electrode reversibility in aqueous electrolytes by using low‐cost antisolvents
Antisolvent addition has been widely studied in crystallization in the pharmaceutical
industries by breaking the solvation balance of the original solution. Here we report a similar …
industries by breaking the solvation balance of the original solution. Here we report a similar …
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …
variants contribute to gene expression, have been performed in heterogeneous brain …
[HTML][HTML] APOE in the bullseye of neurodegenerative diseases: Impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
Compact ion-trap quantum computing demonstrator
I Pogorelov, T Feldker, CD Marciniak, L Postler… - PRX Quantum, 2021 - APS
Quantum information processing is steadily progressing from a purely academic discipline
towards applications throughout science and industry. Transitioning from lab-based, proof-of …
towards applications throughout science and industry. Transitioning from lab-based, proof-of …
[HTML][HTML] Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
A progressive nucleation mechanism enables stable zinc stripping–plating behavior
Y Li, P Wu, W Zhong, C Xie, Y Xie, Q Zhang… - Energy & …, 2021 - pubs.rsc.org
Severe zinc dendrite growth is a formidable challenge in aqueous zinc-ion batteries during
repeated cycles because of the uneven distribution of electric fields on a post-stripping zinc …
repeated cycles because of the uneven distribution of electric fields on a post-stripping zinc …