Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

Widespread adoption of mirror-image biological systems presents difficulties in accessing
the requisite D-protein substrates. In particular, mirror-image phage display has the potential …

The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …

Through mechanistic work and rational design, we have developed the fastest
organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au (III) …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Site‐selective functionalization strategies are in high demand to prepare well‐defined
homogeneous proteins for basic research and biomedical applications. In this regard …

Development of bioconjugation strategies to efficiently modify biomolecules is of key
importance for fundamental and translational scientific studies. Cysteine S-arylation is an …

Understanding protein function is a cornerstone of modern biology. Research centers
worldwide dedicate significant efforts to prepare individual proteins for study, the isolation …

Posttranslational modifications (PTMs) of proteins play central roles in regulating the protein
structure, interactome, and functions. A notable modification site is the aromatic side chain of …