Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …

Prostate cancer is the second leading cause of cancer deaths in the USA. The challenge in
managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic …

The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …

The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress
responses in mammals and as a potential therapeutic target for stress-related disorders …

The Hsp90 chaperone promotes folding and activation of hundreds of client proteins in the
cell through an ATP-dependent conformational cycle guided by distinct cochaperone …