Tau protein kinases: involvement in Alzheimer's disease
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …
[HTML][HTML] Translational control by cytoplasmic polyadenylation in Xenopus oocytes
HE Radford, HA Meijer, CH de Moor - Biochimica et Biophysica Acta (BBA) …, 2008 - Elsevier
Elongation of the poly (A) tails of specific mRNAs in the cytoplasm is a crucial regulatory step
in oogenesis and early development of many animal species. The best studied example is …
in oogenesis and early development of many animal species. The best studied example is …
The mechanosensitive ion channel piezo inhibits axon regeneration
Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal
outgrowth, it is important to investigate whether mechanosensitive ion channels may …
outgrowth, it is important to investigate whether mechanosensitive ion channels may …
[图书][B] Stalin's genocides
NM Naimark - 2010 - degruyter.com
Between the early 1930s and his death in 1953, Joseph Stalin had more than a million of his
own citizens executed. Millions more fell victim to forced labor, deportation, famine, bloody …
own citizens executed. Millions more fell victim to forced labor, deportation, famine, bloody …
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
Long-term potentiation (LTP), a long-lasting enhancement in communication between
neurons, is considered to be the major cellular mechanism underlying learning and memory …
neurons, is considered to be the major cellular mechanism underlying learning and memory …
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
JU Fog, H Khoshbouei, M Holy, WA Owens… - Neuron, 2006 - cell.com
Efflux of dopamine through the dopamine transporter (DAT) is critical for the
psychostimulatory properties of amphetamines, but the underlying mechanism is unclear …
psychostimulatory properties of amphetamines, but the underlying mechanism is unclear …
Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep
The reduced sleep duration previously observed in Camk2b knockout mice revealed a role
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …
CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
X Liu, M Yao, N Li, C Wang, Y Zheng… - Blood, The Journal of …, 2008 - ashpublications.org
Calcium and its major downstream effector, calcium/calmodulin-dependent protein kinase II
(CaMKII), are found to be important for the functions of immune cells. Lipopolysaccharide …
(CaMKII), are found to be important for the functions of immune cells. Lipopolysaccharide …
Non-conducting functions of voltage-gated ion channels
LK Kaczmarek - Nature Reviews Neuroscience, 2006 - nature.com
Various studies, mostly in the past 5 years, have demonstrated that, in addition to their well-
described function in regulating electrical excitability, voltage-dependent ion channels …
described function in regulating electrical excitability, voltage-dependent ion channels …
Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling
Background Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …