mTOR at the nexus of nutrition, growth, ageing and disease

GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

[HTML][HTML] Biological functions of autophagy genes: a disease perspective

B Levine, G Kroemer - Cell, 2019 - cell.com
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

mTOR signaling in growth, metabolism, and disease

RA Saxton, DM Sabatini - Cell, 2017 - cell.com
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

BK Kennedy, DW Lamming - Cell metabolism, 2016 - cell.com
Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR
(mechanistic target of rapamycin), can extend the lifespan of model organisms including …

The mTOR–autophagy axis and the control of metabolism

N Deleyto-Seldas, A Efeyan - Frontiers in cell and developmental …, 2021 - frontiersin.org
The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …

[HTML][HTML] Mechanisms of insulin resistance related to white, beige, and brown adipocytes

MP Czech - Molecular metabolism, 2020 - Elsevier
Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Dihydroxyacetone phosphate signals glucose availability to mTORC1

JM Orozco, PA Krawczyk, SM Scaria, AL Cangelosi… - Nature …, 2020 - nature.com
The mechanistic target of rapamycin complex 1 (mTORC1) kinase regulates cell growth by
setting the balance between anabolic and catabolic processes. To be active, mTORC1 …

The central moTOR of metabolism

J Simcox, DW Lamming - Developmental cell, 2022 - cell.com
The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

LO Huang, A Rauch, E Mazzaferro, M Preuss… - Nature …, 2021 - nature.com
Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …