With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

The biology of healthy and disease-affected cells is often mediated by RNA structures,
desirable targets for small molecule chemical probes and lead medicines. Although …

Certain proteins contain subunits that enable their active translocation across the plasma
membrane into cells. In the specific case of HIV-1, this subunit is the basic domain Tat49–57 …

A decade ago, just five drugs were licensed for the treatment of viral infections. Since then,
greater understanding of viral life cycles, prompted in particular by the need to combat …

Single-nucleotide polymorphisms (SNPs) are the most common type of genetic variation in
man. Genes containing one or more SNPs can give rise to two or more allelic forms of …

Activation of cellular genes typically involves control of transcription initiation by DNA-
binding regulatory proteins. The human immunodeficiency virus transactivator protein, Tat …

Virtually all the compounds that are currently used, or under advanced clinical trial, for the
treatment of HIV infections, belong to one of the following classes:(i) nucleoside/nucleotide …

Researchers' increasing awareness of the essential role played by RNA in many biological
processes and in the progression of disease makes the discovery of new RNA targets an …