Glaucoma is a family of optic neuropathies which cause irreversible but potentially
preventable vision loss. Vision loss in most forms of glaucoma is related to elevated IOP with …

Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

The bulk of aqueous humour outflow resistance is generated in or near the inner wall
endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

Intraocular pressure (IOP) is the critical risk factor for glaucoma, a neurodegenerative
disease and frequent cause of blindness worldwide. As of today, all effective strategies to …

A micropuncture technique involving the use of microcannulas with tip diameters less than 5
μm was used to measure the pressure in Schlemm's canal and in the meshwork at distances …

▪ Abstract The eye transduces light, and we usually do not think of it as a biomechanical
structure. Yet it is actually a pressurized, thick-walled shell that has an internal and external …

Aqueous humor outflow resistance is the primary determinant of intraocular pressure (IOP),
and increased outflow resistance is the basis for elevated IOP associated with glaucoma …

The trabecular meshwork forms most of the resistance to aqueous humor outflow needed for
maintenance of a pressure gradient between intraocular pressure of∼ 17 mmHg and …

purpose. The homeostatic mechanisms responsible for intraocular pressure (IOP) regulation
are not understood. Studies were conducted to evaluate the hypothesis that trabecular …