Highlights•Synaptic scaffolding proteins may bring together adhesion molecules and
receptors.•Adhesion molecules and receptors also directly interact on the neuronal …

The phenotype of autism involves heterogeneous adaptive traits (strengths vs. disabilities),
different domains of alterations (social vs. non-social), and various associated genetic …

Neuroligins are postsynaptic cell-adhesion molecules that bind presynaptic neurexins and
are genetically linked to autism. Neuroligins are proposed to organize synaptogenesis …

Genetic mutations contribute to the etiology of autism spectrum disorder (ASD), a common,
heterogeneous neurodevelopmental disorder characterized by impairments in social …

Developing synapses mature through the recruitment of specific proteins that stabilize
presynaptic and postsynaptic structure and function. Wnt ligands signaling via Frizzled (Fz) …

Neuroligins, postsynaptic cell adhesion molecules that are linked to neuropsychiatric
disorders, are extensively studied, but fundamental questions about their functions remain …

Background Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric
condition, thought to have a significant genetic component. When onset occurs in childhood …

In this review we examine the current understanding of how genetic deficits associated with
neurodevelopmental disorders may impact synapse assembly. We then go on to discuss …

The genomic revolution has begun to unveil the enormous complexity and heterogeneity of
the genetic basis of neurodevelopmental disorders such as such epilepsy, intellectual …

Social affiliative behaviors—engagement in positive (ie, nonaggressive) social approach
and reciprocal social interactions with a conspecific—comprise a construct within the …