Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

Many chronic human diseases, including multiple neurodegenerative diseases, are
associated with deleterious protein aggregates, also called protein amyloids. One common …

Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

Islet amyloid polypeptide (aka IAPP, amylin) is a 37 amino acid hormone that has long been
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …

Global epidemic studies have suggested that coffee consumption is reversely correlated
with the incidence of type 2 diabetes mellitus (T2DM), a metabolic disease. The misfolding of …

Amyloid fiber formation is correlated with pathology in many diseases, including Alzheimer's,
Parkinson's, and type II diabetes. Although β-sheet–rich fibrillar protein deposits define this …

Type-2 diabetes mellitus (T2DM) is one of the most concerning public health problems
because of its high incidence, multiple complications, and difficult treatment. Human islet …