Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

KR Steingart, H Sohn, I Schiller… - Cochrane database …, 2013 - cochranelibrary.com
Background Accurate and rapid detection of tuberculosis (TB) and drug resistance are
critical for improving patient care and decreasing the spread of TB. Xpert® MTB/RIF assay …

Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF

K Weyer, F Mirzayev, GB Migliori… - European …, 2013 - Eur Respiratory Soc
If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future,
improved detection of patients, earlier diagnosis and timely identification of rifampicin …

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

JS Zifodya, JS Kreniske, I Schiller… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health
Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and …

Xpert MTB/RIF results in patients with previous tuberculosis: can we distinguish true from false positive results?

G Theron, R Venter, G Calligaro, L Smith… - Clinical Infectious …, 2016 - academic.oup.com
Background. Patients with previous tuberculosis may have residual DNA in sputum that
confounds nucleic acid amplification tests such as Xpert MTB/RIF. Little is known about the …

Point‐of‐care diagnosis of tuberculosis: Past, present and future

K Dheda, M Ruhwald, G Theron, J Peter… - Respirology, 2013 - Wiley Online Library
Diagnosis represents only one aspect of tuberculosis (TB) control but is perhaps one of the
most challenging. The drawbacks of current tools highlight several unmet needs in TB …

Determinants of PCR performance (Xpert MTB/RIF), including bacterial load and inhibition, for TB diagnosis using specimens from different body compartments

G Theron, J Peter, G Calligaro, R Meldau… - Scientific reports, 2014 - nature.com
The determinants of Xpert MTB/RIF sensitivity, a widely used PCR test for the diagnosis of
tuberculosis (TB) are poorly understood. We compared culture time-to-positivity (TTP; a …

Tuberculosis: From an incurable scourge to a curable disease-journey over a millennium

SK Sharma, A Mohan - Indian Journal of Medical Research, 2013 - journals.lww.com
Globally, tuberculosis (TB) still remains a major public health problem. India is a high TB
burden country contributing to 26 per cent of global TB burden. During 1944-1980, TB …

Accuracy and impact of Xpert MTB/RIF for the diagnosis of smear-negative or sputum-scarce tuberculosis using bronchoalveolar lavage fluid

G Theron, J Peter, R Meldau, H Khalfey, P Gina… - Thorax, 2013 - thorax.bmj.com
Rationale The accuracy and impact of new tuberculosis (TB) tests, such as Xpert MTB/RIF,
when performed on bronchoalveolar lavage fluid (BALF) obtained from patients with sputum …

The cursed duet today: Tuberculosis and HIV-coinfection

S Tiberi, ACC Carvalho, G Sulis, D Vaghela… - La Presse Médicale, 2017 - Elsevier
The tuberculosis (TB) and HIV syndemic continues to rage and are a major public health
concern worldwide. This deadly association raises complexity and represent a significant …

The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce

JG Peter, G Theron, TE Muchinga, U Govender… - PloS one, 2012 - journals.plos.org
Background Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and
tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third …