Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta‐Analysis of Randomized Controlled Trials

D Reale, L Andriolo, S Gursoy… - BioMed Research …, 2021 - Wiley Online Library
Objective. Tranexamic acid (TXA) is increasingly used in orthopedic surgery to reduce blood
loss; however, there are concerns about the risk of venous thromboembolic (VTE) …

Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta‐analysis

J Yates, I Perelman, S Khair, J Taylor, J Lampron… - …, 2019 - Wiley Online Library
BACKGROUND Tranexamic acid (TXA) is an inexpensive therapy effective at minimizing
perioperative blood loss and transfusion. However, it remains underutilized due to safety …

Tranexamic acid in hip fracture surgery: a systematic review and meta-analysis

B Haj-Younes, BS Sivakumar, M Wang… - Journal of …, 2019 - journals.sagepub.com
Aims: The primary objective of this review was to determine whether tranexamic acid (TXA)
reduces transfusion rates in patients undergoing surgery for hip fractures. The secondary …

Is intravenous tranexamic acid effective and safe during hip fracture surgery? An updated meta-analysis of randomized controlled trials

C Xiao, S Zhang, N Long, W Yu, Y Jiang - Archives of orthopaedic and …, 2019 - Springer
Introduction The efficacy and safety of intravenous (IV) tranexamic acid (TXA) during hip
fracture surgery remain controversial. This meta-analysis aimed to assess the efficacy of IV …

Efficacy and safety of tranexamic acid in major non-cardiac surgeries at high risk for transfusion: a systematic review and meta-analysis

BL Houston, K Uminski, T Mutter, E Rimmer… - Transfusion Medicine …, 2020 - Elsevier
Tranexamic acid (TXA) reduces transfusion requirements in cardiac surgery and total hip
and knee arthroplasty, where it has become standard of care. Our objective is to determine …

Efficacy and safety of tranexamic acid in hip fracture surgery. How does dosage affect outcomes: a meta-analysis of randomized controlled trials

P Masouros, G Antoniou, VS Nikolaou - Injury, 2022 - Elsevier
Aim The objective of this study was to assess the efficacy and safety of intravenous TXA
administration in elderly patients undergoing hip fracture surgery focusing on the effect of …

Tranexamic acid safely reduces hidden blood loss in patients undergoing intertrochanteric fracture surgery: a randomized controlled trial

S Zhang, C Xiao, W Yu, N Long, F He, P Cai… - European Journal of …, 2020 - Springer
Purpose To investigate the efficacy and safety of intravenous tranexamic acid (IV-TXA) in
patients undergoing intertrochanteric fracture surgery. Methods A total of 122 patients were …

A systematic review of tranexamic acid usage in patients undergoing femoral fracture surgery

P Zhang, J Bai, J He, Y Liang, P Chen… - Clinical Interventions in …, 2018 - Taylor & Francis
Background Patients undergoing femoral fracture surgery frequently require blood
transfusion. Tranexamic acid (TXA) has been widely used to decrease transfusion rate in …

The efficacy and safety of tranexamic acid in foot and ankle surgery: a systematic review and meta-analysis of comparative clinical studies

SP Mirghaderi, MM Aliasin, M Salimi… - Foot and Ankle Surgery, 2023 - Elsevier
Background A comprehensive review of the current evidence investigating the potential
therapeutic effects of tranexamic acid (TXA) and its safety in foot and ankle surgery is …

Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews

SR Lewis, MW Pritchard, LJ Estcourt… - Cochrane Database …, 2023 - cochranelibrary.com
Background Following hip fracture, people sustain an acute blood loss caused by the injury
and subsequent surgery. Because the majority of hip fractures occur in older adults, blood …